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                Referencias...

Referencias científicas:
  1. WHO guidelines: Risk reduction of cognitive decline and dementia. Geneva: World Health Organization; 2019. 
  2. https://www.sciencemediacentre.org/expert-reaction-to-who-guidelines-on-risk-reduction-of-cognitive-decline-and-dementia/
  3. Nyberg L, Lovden M, Riklund K, Lindenberger U, Backman L. Memory aging and brain maintenance. Trends Cogn Sci. 2012; 16:292–305. 
  4. Fjell A.M., McEvoy L., Holland D., Dale A.M., Walhovd K.B., Alzheimer's Disease Neuroimaging Initative What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus. Prog Neurobiol. 2014a;117:20–40.
  5. https://psychology.fas.harvard.edu/people/mary-whiton-calkins
  6. Zhang & Wang et al., Computerized multi-domain cognitive training reduces brain atrophy in patients with amnestic mild cognitive impairment. Translational Psychiatry (2019a)9:48.
  7. Hill, N. T. et al. Computerized cognitive training in older adults with mild cognitive impairment or dementia: a systematic review and meta-analysis. Am. J. Psychiatry 174, 329–340 (2017). 
  8. Schultz, S. A. et al. Participation in cognitively-stimulating activities is associated with brain structure and cognitive function in preclinical Alzheimer’s disease. Brain. Imaging Behav. 9, 729–736 (2015). 
  9. Anguera, J. A. et al. Video game training enhances cognitive control in older adults. Nature 501, 97–101 (2013). 
  10. Wilson, R. S. et al. Participation in cognitively stimulating activities and risk of incident Alzheimer disease. JAMA 287, 742–748 (2002). 
  11. Wilson, R. S., Scherr, P. A., Schneider, J. A., Tang, Y. and Bennett, D. A. (2007). Relation of Cognitive Activity to Risk of Developing Alzheimer Disease. Neurology, 69, 1911-1920. 
  12. Belleville, S. et al. Improvement of episodic memory in persons with mild cognitive impairment and healthy older adults: evidence from a cognitive intervention program. Dement. Geriatr. Cogn. Disord. 22, 486–499 (2006). 
  13. Savulich, G. et al. Cognitive training using a novel memory game on an ipad in patients with amnestic mild cognitive impairment (aMCI). Int. J. Neuropsychopharmacol. 20, 624–633 (2017). 
  14. Krell-Roesch J, Vemuri P, Pink A, et al. Association Between Mentally Stimulating Activities in Late Life and the Outcome of Incident Mild Cognitive Impairment, With an Analysis of the APOE ε4 Genotype. JAMA Neurol. 2017;74(3):332–338. doi:10.1001/jamaneurol.2016.3822
  15. Yates LA, Ziser S, Spector A, Orrell M (2016) Cognitive leisure activities and future risk of cognitive impairment and dementia: Systematic review and meta-analysis. Int Psychogeriatr 28, 1791–1806.
  16. Kinsella, G. J. et al. Early intervention for mild cognitive impairment: a randomised controlled trial. J. Neurol. Neurosurg. Psychiatry 80, 730–736 (2009). 
  17. Hampstead, B. M. et al. Mnemonic strategy training improves memory for object location associations in both healthy elderly and patients with amnestic mild cognitive impairment: a randomized, single-blind study. Neuropsychology 26, 385–399 (2012). 
  18. Rojas, G. J. et al. Efficacy of a cognitive intervention program in patients with mild cognitive impairment. Int. Psychogeriatr. 25, 825–831 (2013). 
  19. Cespón J, Miniussi C, Pellicciari MC. Interventional programmes to improve cognition during healthy and pathological ageing: Cortical modulations and evidence for brain plasticity. Ageing Res Rev 2018;43:81-98. 
  20. Gutchess, A. Plasticity of the aging brain: new directions in cognitive neuroscience. Science 346, 579–582 (2014). 
  21. Draganski, B. et al. Neuroplasticity: changes in grey matter induced by training. Nature 427, 311–312 (2004). 
  22. Hubener, M. & Bonhoeffer, T. Neuronal plasticity: beyond the critical period. Cell 159, 727–737 (2014).
  23. Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, et al. Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria. Lancet Neurol. (2014) 6:614–29. 
  24. Vuoksimaa, E., Panizzon, M. S., Chen, C. H., Eyler, L. T., Fennema- Notestine, C., Fiecas, M. J., et al. (2013). Cognitive reserve moderates the association between hippocampal volume and episodic memory in middle age. Neuropsychologia 51, 1124–1131.
  25. Mondini S, Madella I, Zangrossi A, et al. Cognitive reserve in dementia: implications for cognitive training. Front Aging Neurosci. 2016;8:84.
  26. Staff R.T., Hogan M.J., Williams D.S., Whalley L.J. Intellectual engagement and cognitive ability in later life (the “use it or lose it” conjecture): longitudinal, prospective study. BMJ. 2018;363:k4925.
  27. C. Qiu, L.  Fratiglioni. Aging without Dementia is Achievable: Current Evidence from Epidemiological Research. Journal of Alzheimer’s Disease 62 (2018) 933–942.
  28. Stern, Y. Cognitive reserve: implications for assessment and intervention. Folia Phoniatr. Et. Logop. 65, 49–54 (2013). 
  29. Tromp, D., Dufour, A., Lithfous, S., Pebayle, T., Despres, O., 2015. Episodic memory in normal aging and Alzheimer disease: insights from imaging and behavioral studies. Ageing Res. Rev. 24 (Pt B), 232–262. 
  30. Barnett J.H., Blackwell A.D., Sahakian B.J., Robbins T.W. (2016) The Paired Associates Learning (PAL) Test: 30 Years of CANTAB Translational Neuroscience from Laboratory to Bedside in Dementia Research. In: Robbins T.W., Sahakian B.J. (eds) Translational Neuropsychopharmacology. Current Topics in Behavioral Neurosciences, vol 28. Springer, Cham  
  31. Tulving E. Episodic memory and autonoesis: Uniquely human? In: The missing link in cognition: Origins of self-reflective consciousness, ed. H. S. Terrace & J. Metcalfe, pp. 3–56. 2005 Oxford University Press. 
  32. Dharani, K. The Biology of Thought : A Neuronal Mechanism in the Generation of Thought–A New Molecular Model. Book 2015
  33. Carl A Gold. Memory loss in Alzheimer's disease: implications for development of therapeutics. Expert Rev Neurother. 2008 Dec; 8(12): 1879-1891.
  34.  Harada CN, , Natelson Love MC, , Triebel KL: Normal cognitive aging. Clin Geriatr Med 2013; 29:737–752.
  35. Preventing Alzheimer’s Disease with Cognitive Training (PACT) Trial
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